Encountered weird InfoPath bug. Had an Approval Workflow with the InfoPath 2007 Web Form (MOSS). User had problems submitting the Form, click on the submit button was doing nothing. Reopening the Form was enough to submit. I watched how user worked with the Form, and noticed that the user was double clicking on the email link, which was causing the form to load twice (in two IE tabs). Changing this habit to clicking only once - solved the problem completely.
I have no idea why double loading the form was preventing it from submitting, but that's what it was.